Laukkanen Päivi, Koskela Pentti, Pukkala Eero, Dillner Joakim, Läärä Esa, Knekt Paul, Lehtinen Matti
Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.
National Public Health Institute, Helsinki and Oulu, Mannerheimintie 166, 00300 Helsinki, Finland.
J Gen Virol. 2003 Aug;84(Pt 8):2105-2109. doi: 10.1099/vir.0.18995-0.
Human papillomavirus (HPV) type 16 is the major cause of cervical carcinoma, the incidence of which is decreasing in western countries. In Finland the incidence is, however, increasing in women aged <40 years, but possible underlying changes in HPV-16 epidemiology are unknown. To assess incidence trends of HPV infections, paired sera from a random sample of 8000 women with two pregnancies/sera within 5 years, taken from the serum bank of the Finnish Maternity Cohort (1983-98), were analysed for HPV-6, -11 and -16 antibodies. For 23-31-year-old women, HPV-16 incidence increased over the period 1983-97. HPV-16 seroprevalence increased from 17% in 1983-85 to 24% in 1995-97, but HPV-6 and HPV-11 prevalence was stable at 9-12% throughout the study period. Epidemic spread of the oncogenic HPV-16, but not the non-oncogenic HPV-types, throughout the 1980s and 1990s preceded an increase in the incidence of cervical carcinoma in fertile-aged Finnish women.
人乳头瘤病毒16型（HPV - 16）是宫颈癌的主要病因，在西方国家其发病率正在下降。然而，在芬兰，40岁以下女性的发病率却在上升，但是HPV - 16流行病学中可能存在的潜在变化尚不清楚。为了评估HPV感染的发病率趋势，从芬兰孕产妇队列（1983 - 1998年）血清库中随机抽取了8000名在5年内有两次妊娠的女性的配对血清，分析其中HPV - 6、- 11和 - 16抗体。对于23 - 31岁的女性，1983 - 1997年期间HPV - 16发病率有所上升。HPV - 16血清阳性率从1983 - 1985年的17%上升至1995 - 1997年的24%，但在整个研究期间，HPV - 6和HPV - 11的阳性率稳定在9 - 12%。在20世纪80年代和90年代，致癌性HPV - 16而非非致癌性HPV类型的流行传播，先于芬兰育龄妇女宫颈癌发病率的上升。
