Heuner Klaus, Steinert Michael
Institut für Molekulare Infektionsbiologie, Julius-Maximilians Universität Würzburg, Würzburg, Germany.
Int J Med Microbiol. 2003 Jun;293(2-3):133-43. doi: 10.1078/1438-4221-00259.
Legionalla pneumophila is a human pathogen causing atypical pneumonia. It is a monopolar flagellated gram-negative bacterium. Flagellation of L. pneumophila is life cycle dependent and the expression of flagella is genetically linked to the virulence phenotype. Non-flagellated mutants of L. pneumophila are less infectious for macrophages and amoebae compared to the wild type. The flagellar operon is expressed in a hierarchical manner, and different sigma factors and transcriptional regulators are involved in this cascade of gene regulation. The genome sequence of L. pneumophila was used to identify putative regulatory elements of various flagellar operons. Preliminary reports about regulators which are involved in the link between virulence gene regulation and flagellation are discussed.
嗜肺军团菌是一种可导致非典型肺炎的人类病原体。它是一种单极鞭毛革兰氏阴性菌。嗜肺军团菌的鞭毛形成依赖于生命周期，鞭毛的表达在基因上与毒力表型相关。与野生型相比，嗜肺军团菌的无鞭毛突变体对巨噬细胞和变形虫的感染性较低。鞭毛操纵子以分级方式表达，不同的σ因子和转录调节因子参与了这一基因调控级联反应。嗜肺军团菌的基因组序列被用于鉴定各种鞭毛操纵子的假定调控元件。文中讨论了关于参与毒力基因调控与鞭毛形成之间联系的调节因子的初步报告。
