Xiong Chiyi, Zhang Junyi, Davis Peg, Wang Wei, Ying Jinfa, Porreca Frank, Hruby Victor J
Department of Chemistry, University of Arizona, 1306 E. University Blvd., Tucson, AZ 85721, USA.
Chem Commun (Camb). 2003 Jul 7(13):1598-9. doi: 10.1039/b302235h.
Novel constrained beta-turn dipeptide mimetics, 8-phenyl thiaindolizidinone amino acids 3, have been synthesized stereoselectively and incorporated into Leu-enkephalin peptides as a replacement of dipeptide Gly3-Phe4 to afford four individual isomers of Leu-enkephalin analogues 6.
新型受限β-转角二肽模拟物，8-苯基硫代吲哚嗪酮氨基酸3，已通过立体选择性合成，并作为二肽Gly3-Phe4的替代物掺入亮氨酸脑啡肽肽中，得到亮氨酸脑啡肽类似物6的四种单独异构体。
