Tamimi Rulla, Lagiou Pagona, Vatten Lars J, Mucci Lorelei, Trichopoulos Dimitrios, Hellerstein Susan, Ekbom Anders, Adami Hans-Olov, Hsieh Chung-Cheng
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
Cancer Epidemiol Biomarkers Prev. 2003 Jul;12(7):647-50.
The aim of this study is to prospectively assess pregnancy hormone levels as correlates of subsequent development of pre-eclampsia, a condition that has been shown to be inversely associated with breast cancer risk in the offspring. A cohort of 260 Caucasian women in Boston, Massachusetts, was followed through pregnancy. Maternal blood was collected at the 16th and 27th weeks of gestation, and 18 women were diagnosed with pre-eclampsia after blood collection. Information on sociodemographic variables and risk factors of pre-eclampsia was collected through an interviewer-administered questionnaire and review of medical records. At the 16th week, there was a nonsignificant positive association between progesterone levels and pre-eclampsia [relative risk (RR) = 1.63, 95% confidence interval (CI), 0.97-2.74, per 1 SD increase]. By the 27th week, the association between progesterone and pre-eclampsia was strengthened (RR = 2.65, 95% CI, 1.46-4.81, per SD), and sex hormone-binding globulin levels were somewhat inversely related to pre-eclampsia (RR = 0.61, 95% CI, 0.31-1.20, per SD). No difference was found with respect to prolactin, estradiol, and estriol levels. Our findings indicate that progesterone may have a role in the late manifestation of pre-eclampsia pathology but are also compatible with the hypothesis that increases in progesterone represent an early compensatory mechanism.
本研究的目的是前瞻性评估妊娠激素水平与子痫前期后续发展的相关性，子痫前期已被证明与后代患乳腺癌的风险呈负相关。对马萨诸塞州波士顿的260名白人女性队列进行了孕期跟踪。在妊娠第16周和第27周采集孕妇血液，采血后18名女性被诊断为子痫前期。通过访员管理的问卷和病历审查收集了社会人口统计学变量和子痫前期风险因素的信息。在第16周时，孕酮水平与子痫前期之间存在无显著意义的正相关[相对风险（RR）=1.63，95%置信区间（CI），0.97 - 2.74，每增加1个标准差]。到第27周时，孕酮与子痫前期之间的关联增强（RR = 2.65，95% CI，1.46 - 4.81，每标准差），性激素结合球蛋白水平与子痫前期呈一定程度的负相关（RR = 0.61，95% CI，0.31 - 1.20，每标准差）。在催乳素、雌二醇和雌三醇水平方面未发现差异。我们的研究结果表明，孕酮可能在子痫前期病理的后期表现中起作用，但也与孕酮升高代表一种早期代偿机制的假说相符。
