Wellik Deneen M, Capecchi Mario R
Howard Hughes Medical Institute and University of Utah, Salt Lake City, UT 84112, USA.
Science. 2003 Jul 18;301(5631):363-7. doi: 10.1126/science.1085672.
Mice in which all members of the Hox10 or Hox11 paralogous group are disrupted provide evidence that these Hox genes are involved in global patterning of the axial and appendicular skeleton. In the absence of Hox10 function, no lumbar vertebrae are formed. Instead, ribs project from all posterior vertebrae, extending caudally from the last thoracic vertebrae to beyond the sacral region. In the absence of Hox11 function, sacral vertebrae are not formed and instead these vertebrae assume a lumbar identity. The redundancy among these paralogous family members is so great that this global aspect of Hox patterning is not apparent in mice that are mutant for five of the six paralogous alleles.
Hox10或Hox11旁系同源基因家族所有成员均被破坏的小鼠提供了证据，表明这些Hox基因参与了轴骨和附肢骨骼的整体模式形成。在缺乏Hox10功能的情况下，不会形成腰椎。相反，肋骨从所有后部椎骨突出，从最后一个胸椎向尾侧延伸至骶骨区域之外。在缺乏Hox11功能的情况下，不会形成骶椎，相反，这些椎骨呈现腰椎特征。这些旁系同源家族成员之间的冗余性非常大，以至于在六个旁系同源等位基因中有五个发生突变的小鼠中，Hox模式形成的这一整体方面并不明显。
