Myslivecek J, Trojan S
Institute of Physiology, First Medical Faculty, Charles University, Prague, Czech Republic.
Gen Physiol Biophys. 2003 Mar;22(1):3-14.
Receptor activation results in homologous regulation and can also affect other types of receptors (a process that has been reported to heterologous regulation). Heart cells express subtypes of muscarinic receptors and adrenoceptors, almost antagonistic in their action (M2 muscarinic receptors and beta1-adrenoceptors). Therefore, they provide an excellent model of heterologous regulation. Moreover, the minor subtypes of adrenoceptors and muscarinic receptors have been identified in the heart cells. The physiological significance of the minor subtypes is now under keen investigation and their function can be considered as complementary to the major subtypes. Taken together, it seems that the minor subtypes may play an important role in the receptor-heart function homeostasis and that heterologous regulation seems to exist in many heart receptor types and in the above mentioned pair of receptors.
受体激活会导致同源调节，也会影响其他类型的受体（这一过程被报道为异源调节）。心脏细胞表达毒蕈碱受体和肾上腺素能受体的亚型，它们的作用几乎相互拮抗（M2毒蕈碱受体和β1肾上腺素能受体）。因此，它们提供了一个异源调节的极佳模型。此外，已在心脏细胞中鉴定出肾上腺素能受体和毒蕈碱受体的次要亚型。次要亚型的生理意义目前正在深入研究中，其功能可被视为对主要亚型的补充。综上所述，次要亚型似乎可能在受体 - 心脏功能稳态中发挥重要作用，并且异源调节似乎存在于许多心脏受体类型以及上述这对受体中。
