Malisan Florence, Testi Roberto
Department of Experimental Medicine and Biochemical Sciences, University Tor Vergata, Via Montpellier, 1. 00133 Rome, Italy.
Curr Med Chem. 2003 Aug;10(16):1573-80. doi: 10.2174/0929867033457188.
Mitochondria are key players in fundamental processes such as energy production and adaptive responses to cellular stress, including apoptosis. Mitochondrial membranes may undergo permeabilization when perturbed by a number of intracellular stress mediators, and consequently may allow the release of intramitochondrial proteins. This event triggers and amplifies the cellular apoptotic program, provided sufficient energy is available. Mitochondrial membranes are therefore both targets and regulators of intracellular pathways controlling cell fate. Evidence is emerging that the integration and biological outcome of these pathways might be critically dependent on the unique lipid composition of mitochondrial membranes.
线粒体是能量产生以及对包括细胞凋亡在内的细胞应激进行适应性反应等基本过程的关键参与者。当受到多种细胞内应激介质的干扰时，线粒体膜可能会发生通透性改变，进而可能导致线粒体内蛋白质的释放。如果有足够的能量，这一事件会触发并放大细胞凋亡程序。因此，线粒体膜既是控制细胞命运的细胞内信号通路的靶点，也是调节因子。越来越多的证据表明，这些信号通路的整合及生物学结果可能严重依赖于线粒体膜独特的脂质组成。
