作为抗寄生虫治疗靶点的DNA拓扑异构酶

DNA topoisomerases as targets for antiprotozoal therapy.

作者信息

Bakshi R P, Shapiro T A

机构信息

Department of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA.

出版信息

Mini Rev Med Chem. 2003 Sep;3(6):597-608. doi: 10.2174/1389557033487863.

DOI:10.2174/1389557033487863

PMID:12871162

Abstract

Diseases caused by parasitic protozoa present a health problem of immense magnitude, and there is an urgent need for safe and effective new therapies. DNA topoisomerases are clinically relevant targets for anti-cancer and anti-bacterial agents. Inhibitor studies on parasite topoisomerases have revealed that these enzymes have great promise as molecular targets for anti-parasitics, and have helped to dissect the basic biology of DNA topoisomerases in these organisms. This review provides a brief introduction to DNA topoisomerases and anti-topoisomerase drugs, and an overview of studies on protozoal DNA topoisomerases and their inhibitors.

摘要

由寄生原生动物引起的疾病构成了一个极其严重的健康问题，因此迫切需要安全有效的新疗法。DNA拓扑异构酶是抗癌和抗菌药物的临床相关靶点。对寄生虫拓扑异构酶的抑制剂研究表明，这些酶作为抗寄生虫药物的分子靶点具有很大潜力，并有助于剖析这些生物体中DNA拓扑异构酶的基础生物学。本文综述简要介绍了DNA拓扑异构酶和抗拓扑异构酶药物，并概述了有关原生动物DNA拓扑异构酶及其抑制剂的研究。