Biñas M, Johnson A M
Department of Microbiology, School of Biological and Biomedical Sciences, University of Technology, Sydney, Gore Hill, NSW, Australia.
Appl Parasitol. 1994 Sep;35(3):157-68.
Chemotherapy against protozoan diseases has been practised since ancient times. Although still widely used, antiparasitic drugs are seldom completely effective. Complete elimination of an extensive protozoan infection usually requires a combination of drugs which target parasitic mechanisms very similar to the human host, as manifested by a multitude of side effects of varying severity. Furthermore, there is an escalating problem of widespread resistance to commonly used chemotherapeutic agents. Here we present an alternative strategy for the design of antiprotozoal agents using the principal enzyme involved in DNA replication as a possible drug target--DNA polymerase.
针对原生动物疾病的化疗自古代就已实施。尽管抗寄生虫药物仍被广泛使用，但很少能完全有效。彻底消除广泛的原生动物感染通常需要联合使用多种药物，这些药物针对的寄生机制与人类宿主非常相似，这表现为程度各异的多种副作用。此外，对常用化疗药物的广泛耐药问题日益严重。在此，我们提出一种设计抗原生动物药物的替代策略，即利用参与DNA复制的主要酶——DNA聚合酶作为可能的药物靶点。
