Lou Boliang, Yang Kexin
Advanced SynTech, 9800 Bluegrass Parkway, Louisville, KY 40299, USA.
Mini Rev Med Chem. 2003 Sep;3(6):609-20. doi: 10.2174/1389557033487872.
A hydroxamic acid moiety has been demonstrated as the key structural element in many highly potent and selective inhibitors against a variety of metalloprotease enzymes, such as MMPs, TACE, HDAC, PDF, etc. Over the last several years, there has been a rapid growth of literature and patent applications dealing with the development of the hydroxamic acid-based inhibitors. This review highlights the most recent examples to show their potential therapeutic applications.
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