Ruiz-Argüelles Alejandro, Rivadeneyra-Espinoza Liliana, Alarcón-Segovia Donato
Department of Immunology, Laboratorios Clínicos de Puebla, México.
Curr Pharm Des. 2003;9(23):1881-7. doi: 10.2174/1381612033454379.
The dogmatic and at one time prevalent concept that intact antibody molecules were not able to enter into viable cells has now been modified due to the availability of a large amount of experimental findings and clinical observations that indicate otherwise. Penetration of mature autoantibodies into living cells might participate in the pathogenesis of diverse autoimmune diseases, through inducing apoptosis of healthy tissues and cells, but also by contributing to the breakdown of self-tolerance through presentation of self-antigens to the immune system. Conversely, the penetration of naturally occurring autoantibodies into immature lymphoid cells might have a physiological role in the edition of the immune repertoire in healthy individuals. Increasing interest is being paid to the potential immunotherapeutic role of penetrating antibodies as tools to deliver drugs, isotopes or genes into cells.
过去曾盛行的教条观念认为完整的抗体分子无法进入活细胞，如今这一观念已因大量实验结果和临床观察表明并非如此而得到修正。成熟自身抗体进入活细胞可能参与多种自身免疫性疾病的发病机制，既通过诱导健康组织和细胞凋亡，也通过将自身抗原呈递给免疫系统从而导致自身耐受性的破坏。相反，天然存在的自身抗体进入未成熟淋巴细胞可能在健康个体免疫库的编辑中具有生理作用。作为将药物、同位素或基因导入细胞的工具，穿透性抗体的潜在免疫治疗作用正受到越来越多的关注。
