Tarbichi Abdul Ghani S, Rowley James A, Shkoukani Mahdi A, Mahadevan Karthik, Badr M Safwan
Wayne State University Sleep Research Laboratory, John D. Dingell Veterans Affairs Medical Center, 4646 John R, Detroit, MI 48201, USA.
Respir Physiol Neurobiol. 2003 Aug 14;137(1):41-50. doi: 10.1016/s1569-9048(03)00111-3.
Altered chemoresponsiveness has been postulated to explain the gender difference in the incidence of sleep disordered breathing (SDB). The purpose of this investigation was to ascertain a gender difference in the effect of hypocapnic hypoxia on ventilation. Hypocapnic hypoxia was induced in stable NREM sleep for 3 min periods. In the first analysis, hypoxic ventilatory response in a steady state (SHVR) was defined as the amount of change in minute ventilation (VI) between mean room air (RA) and hypoxia divided by the change in Sa O2 between RA and hypoxia (DeltaVI/DeltaSa O2). The mean group SHVR values were 0.23+/-0.15 and 0.20+/-0.10 L/min per %SaO2, for men and women, respectively (P = ns). In the second analysis, we analyzed the decline in ventilatory parameters after the cessation of hypoxia. There was no difference in VI between the genders (men, 5.6+/-1.7 L/min vs. women, 4.9+/-1.9 L/min, P = ns). We conclude that the gender difference in SDB is not explained by a difference in the ventilatory response to hypocapnic hypoxia.
化学敏感性改变被认为可解释睡眠呼吸障碍（SDB）发病率的性别差异。本研究的目的是确定低碳酸血症性缺氧对通气影响的性别差异。在稳定的非快速眼动睡眠期诱导低碳酸血症性缺氧3分钟。在首次分析中，稳态下的低氧通气反应（SHVR）定义为平均室内空气（RA）与低氧状态下分钟通气量（VI）的变化量除以RA与低氧状态下SaO2的变化量（ΔVI/ΔSaO2）。男性和女性的平均组SHVR值分别为0.23±0.15和0.20±0.10L/（min·%SaO2）（P=无显著性差异）。在第二次分析中，我们分析了缺氧停止后通气参数的下降情况。两性之间的VI无差异（男性，5.6±1.7L/min；女性，4.9±1.9L/min，P=无显著性差异）。我们得出结论，SDB的性别差异不能用对低碳酸血症性缺氧的通气反应差异来解释。
