2,4-二硝基苯酚对仓鼠颊囊9,10-二甲基-1,2-苯并蒽致癌作用的抑制

Inhibition by 2,4-dinitrophenol of 9,10-dimethyl-1,2-benzanthracene carcinogenesis in the hamster cheek pouch.

作者信息

Levij I S, Rubin D

出版信息

Oncology. 1975;31(5-6):334-7. doi: 10.1159/000225038.

Abstract

After topical treatment of cheek pouches of 10 hamsters with 9,10-dimethyl-1,2-benzanthracene and 2,4-dinitrophenol for 10 weeks no carcinomas developed in any of the animals. After treatment of 10 animals with the carcinogen only, there were 49 carcinomas in the 8 survivors. Inhibition of chemical carcinogenesis by dinitrophenol was tentatively attributed to suppression of ATP synthesis and to activation of ATPase by dinitrophenol.

摘要

用9,10 - 二甲基 - 1,2 - 苯并蒽和2,4 - 二硝基苯酚对10只仓鼠的颊囊进行局部处理10周后，所有动物均未发生癌变。仅用致癌物处理10只动物后，8只存活动物中有49个癌。二硝基苯酚对化学致癌作用的抑制作用初步归因于ATP合成的抑制以及二硝基苯酚对ATP酶的激活。