菲和二甲基萘对仓鼠颊囊DMBA致癌作用的抑制
Inhibition of DMBA carcinogenesis of hamster buccal pouch by phenanthrene and dimethylnaphthalene.
作者信息
Malament D S, Shklar G
出版信息
Carcinogenesis. 1981;2(8):723-9. doi: 10.1093/carcin/2.8.723.
PMID:6793258
Abstract
Phenanthrene (Phe) and to a lesser degree 1,4-dimethylnaphthalene (DMeN) were each found to retard the development of epidermoid carcinomas in hamster buccal pouch induced by the thrice weekly application of a 0.5 per cent solution of 7,12-dimethylbenz[a]anthracene (DMBA) in heavy mineral oil.
摘要
研究发现，菲（Phe）以及程度稍轻的1,4 - 二甲基萘（DMeN），均可延缓通过每周三次在仓鼠颊囊中涂抹0.5%的7,12 - 二甲基苯并[a]蒽（DMBA）重质矿物油溶液所诱发的表皮样癌的发展。
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