一名丙型肝炎病毒阳性患者的巨球蛋白血症和膜增生性肾小球肾炎
Macroglobulinemia and membranoproliferative glomerulonephritis in a hepatitis C virus-positive patient.
作者信息
Akashi Y, Inoh M, Gamou N, Yoshimune N, Kinashi M, Ohbayashi S, Kurata N
机构信息
Department of Internal Medicine, Kinashi Ohbayashi Hospital, Tahamatu City, Kagawa, Japan.
出版信息
Clin Nephrol. 2003 Jul;60(1):49-52. doi: 10.5414/cnp60049.
A 72-year-old female was admitted to our hospital for massive proteinuria. She had previously been diagnosed with hepatitis C virus (HCV) infection and macroglobulinemia. Renal histological examination demonstrated membranoproliferative glomerulonephritis (MPGN), and type 2 cryoglobulinemia was positive in her serum. It is generally recognized that MPGN is the most common nephritis associated with HCV infection and cryoglobulinemia, but this is the first report of an HCV-infected patient with macroglobulinemia associated with MPGN. After treatment with prednisolone and melphalan, proteinuria disappeared, but macroglobulinemia and cryoglobulinemia were not improved.
一名72岁女性因大量蛋白尿入院。她此前被诊断为丙型肝炎病毒（HCV）感染和巨球蛋白血症。肾脏组织学检查显示为膜增生性肾小球肾炎（MPGN），其血清中2型冷球蛋白血症呈阳性。一般认为MPGN是与HCV感染和冷球蛋白血症相关的最常见肾炎，但这是首例HCV感染合并巨球蛋白血症且与MPGN相关的患者报告。经泼尼松龙和马法兰治疗后，蛋白尿消失，但巨球蛋白血症和冷球蛋白血症未得到改善。
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