Hillman Gilda G, Maughan Richard L, Grignon David J, Yudelev Mark, Che Mingxin, Abrams Judith, Wang Yu, Layer Andrey, Wright Jennifer L, Rubio Johanna, Forman Jeffrey D
Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine and Harper Hospital, Detroit, MI 48201, USA.
Int J Radiat Oncol Biol Phys. 2003 Aug 1;56(5):1426-37. doi: 10.1016/s0360-3016(03)00438-3.
To improve the outcome of radiotherapy for prostate carcinoma bone tumors, we investigated bone tumor irradiation with photons or neutrons followed by interleukin 2 (IL-2) therapy in a tumor model.
Implantation of PC-3 cells in nude mouse femur cavity induced a bone tumor that progressed to the formation of a palpable tumor, at the hip joint, by Day 20. Established bone tumors were irradiated with photons or neutrons, and a day later, mice were treated with IL-2 therapy for 3 weekly cycles.
PC-3 bone tumors responded to radiation with photons or neutrons in a dose-dependent manner. Combination of photon or neutron radiation with IL-2 therapy increased tumor growth delay, compared to that with photons or neutrons alone. Radiation alone or combined with IL-2 significantly increased mouse survival compared to that with IL-2 or no treatment. After combined therapy, a complete inhibition of bone tumor growth was observed in 45% to 50% of the mice. Histologically, the combined therapy resulted in greater tumor destruction associated with fibrosis, new bone formation, and inflammatory infiltrates than that observed with each modality alone.
The efficacy of tumor irradiation with neutrons or photons was enhanced by IL-2 therapy for the treatment of prostate carcinoma bone tumors.
为了提高前列腺癌骨肿瘤的放射治疗效果，我们在一个肿瘤模型中研究了用光子或中子照射骨肿瘤后再进行白细胞介素2（IL-2）治疗的情况。
将PC-3细胞植入裸鼠股骨腔内诱导形成骨肿瘤，到第20天时肿瘤进展至髋关节处可触及。对已形成的骨肿瘤用光子或中子进行照射，一天后，对小鼠进行IL-2治疗，共3个每周疗程。
PC-3骨肿瘤对光子或中子辐射呈剂量依赖性反应。与单独使用光子或中子相比，光子或中子辐射与IL-2治疗联合使用可延长肿瘤生长延迟时间。与单独使用IL-2或不治疗相比，单独放疗或放疗联合IL-2均可显著提高小鼠存活率。联合治疗后，45%至50%的小鼠骨肿瘤生长被完全抑制。组织学检查显示，与单独使用每种治疗方式相比，联合治疗导致的肿瘤破坏更大，伴有纤维化、新骨形成和炎性浸润。
IL-2治疗可增强用中子或光子照射肿瘤对前列腺癌骨肿瘤的治疗效果。
