Prabhakaran K, Harris E B, Randhawa B, Hastings R C
Biochemistry Department, Hansen's Disease Center, Louisiana State University, Baton Rouge 70894.
Microbios. 1992;72(291):137-42.
The multiplication of Mycobacterium leprae in foot pads of experimentally-infected mice was suppressed by intramuscular administration of ampicillin combined with sulbactam or YTR-830H, two potent inhibitors of beta-lactamase in the bacteria. The antibiotic or the inhibitors by themselves were inactive. Ampicillin/sulbactam also inhibited the growth of drug-resistant M. leprae which grew in the presence of rifampin or dapsone. The finding provides a new approach to treat leprosy and to overcome drug resistance of the mycobacteria.
通过肌肉注射氨苄西林联合舒巴坦或YTR - 830H（两种强效的细菌β - 内酰胺酶抑制剂），可抑制实验感染小鼠足垫中麻风分枝杆菌的增殖。单独使用抗生素或抑制剂均无活性。氨苄西林/舒巴坦还可抑制在利福平或氨苯砜存在下生长的耐药麻风分枝杆菌的生长。这一发现为治疗麻风病和克服分枝杆菌耐药性提供了一种新方法。
