Parisi G, Squadrone N P, Rojo S, Muzii U, Molino O, Chiarelli A
Unità Operativa Pediatrico Neonatologica, Regione Abruzzo-ULSS n. 15-Vasto (Chieti), Presidio Ospedaliero.
Minerva Pediatr. 1992 Oct;44(10):459-67.
The Authors report a case of two pre-term monocorial twins affected by HSV-1 infection (Herpes Simplex Virus type 1), with generalized sepsis and involvement of the central nervous system (CNS), born by mother with primary infection who presented a typical vesicular eruption a week before delivery. As the HSV-1 was a disseminated type and the CNS was involved in both the twins, the diagnosis was based on clinical and laboratory findings (specific IgM and IgG) and on the use of Delpech-Lichtblau antibody liquoral index, a significant results both in the first and the second twin. Intensive care and early specific treatment with Acyclovir allowed a slow but progressive improvement of the twins' clinical picture. The antibody liquoral index may therapy of the viral sepsis cases involving the CNS, more than the cultural or antigen isolation of the treated virus.
作者报告了一例双绒毛膜单羊膜囊双胎早产儿感染1型单纯疱疹病毒（HSV-1）的病例，患儿出现全身性败血症并累及中枢神经系统（CNS），其母亲在分娩前一周出现典型水疱疹，为原发性感染。由于HSV-1为播散型且两个胎儿的中枢神经系统均受累，诊断基于临床和实验室检查结果（特异性IgM和IgG）以及德尔佩什-利希特布劳脑脊液抗体指数，该指数在两个胎儿中均有显著结果。重症监护和早期使用阿昔洛韦进行特异性治疗使患儿的临床症状缓慢但逐步改善。脑脊液抗体指数在涉及中枢神经系统的病毒性败血症病例的治疗中可能比所治疗病毒的培养或抗原分离更有价值。
