Israel-Mardirosian Noobar, Adler Lee P
Department of Diagnostic Imaging, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA.
Curr Opin Oncol. 2003 Jul;15(4):327-30. doi: 10.1097/00001622-200307000-00008.
The purpose of this review is to underscore the value of positron emission tomography (PET) in the management of patients with soft tissue sarcomas. Although the most essential step in the diagnostic evaluation of soft tissue sarcomas is tumor biopsy, functional imaging techniques is growing and becoming more popular than before. PET scan traces molecular and cellular activities of normal and tumor cells through the use of radiotracers that engage in cell metabolism. The most important and widely used tracer is fluorodeoxyglucose (18FDG). PET scan usefulness is not limited to its ability to differentiate benign from malignant lesions. The scan can detect intralesional morphologic variation which is especially true in soft tissue sarcomas, it can predict tumor grade, and it is of value in staging, restaging and prognosis. As for the time, PET is not meant to replace tissue biopsy but rather complement the biopsy to better understand the biological behavior of soft tissue sarcomas.
本综述的目的是强调正电子发射断层扫描（PET）在软组织肉瘤患者管理中的价值。尽管软组织肉瘤诊断评估中最关键的步骤是肿瘤活检，但功能成像技术正在发展，且比以往更受欢迎。PET扫描通过使用参与细胞代谢的放射性示踪剂来追踪正常细胞和肿瘤细胞的分子及细胞活动。最重要且应用最广泛的示踪剂是氟脱氧葡萄糖（18FDG）。PET扫描的作用不仅限于区分良性和恶性病变。该扫描能够检测病变内的形态学变化，这在软组织肉瘤中尤为如此，它可以预测肿瘤分级，并且在分期、再分期及预后方面具有价值。至于时机，PET并非旨在取代组织活检，而是对活检起到补充作用，以便更好地了解软组织肉瘤的生物学行为。
