Voshaar Richard Oude, Gorgels Wim, Mol Audrey, van Balkom Anton, Breteler Marinus, van de Lisdonk Eloy, Mulder Jan, Zitman Frans
Department of Psychiatry (hp 333), University Medical Centre St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Fam Pract. 2003 Aug;20(4):370-2. doi: 10.1093/fampra/cmg405.
Long-term results of minimal intervention strategies to cut down benzodiazepine use are not available.
To evaluate the relapse rate over a two-year period and to search for predictors of relapse among patients who quit benzodiazepine use after receiving a discontinuation letter.
Baseline assessment and prospective monitoring of the medical records of 109 patients who quit long-term benzodiazepine use after a minimal intervention strategy in general practice.
After 819 +/- 100 days of follow-up, 53 (49%) patients had remained completely abstinent. Two independent predictors of relapse were identified by Cox regression analysis: use of more than 10 mg diazepam equivalent (RR = 2.4 [1.2 - 4.7]) and poor general health perception (RR = 0.98 [0.97 - 0.99]).
Short-term success rates after a minimal intervention were maintained well during long-term follow-up. High-dose users have the highest risk of relapse.
减少苯二氮䓬类药物使用的最小干预策略的长期结果尚不可知。
评估两年期间的复发率，并在收到停药信后停用苯二氮䓬类药物的患者中寻找复发的预测因素。
对109例在基层医疗中采用最小干预策略后停用长期苯二氮䓬类药物的患者的病历进行基线评估和前瞻性监测。
经过819±100天的随访，53例（49%）患者保持完全戒断。通过Cox回归分析确定了两个独立的复发预测因素：使用超过10毫克地西泮等效物（风险比=2.4[1.2-4.7]）和总体健康感知较差（风险比=0.98[0.97-0.99]）。
在长期随访期间，最小干预后的短期成功率得到了很好的维持。高剂量使用者复发风险最高。
