在能量下坡景观上的快速蛋白质折叠。
Fast protein folding on downhill energy landscape.
作者信息
Cavalli Andrea, Haberthür Urs, Paci Emanuele, Caflisch Amedeo
机构信息
Department of Biochemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
出版信息
Protein Sci. 2003 Aug;12(8):1801-3. doi: 10.1110/ps.0366103.
Abstract
Proteins fold in a time range of microseconds to minutes despite the large amount of possible conformers. Molecular dynamics simulations of a three-stranded antiparallel beta-sheet peptide (for a total of 12.6 microsec and 72 folding events) show that at the melting temperature the unfolded state ensemble contains many more conformers than those sampled during a folding event.
摘要
尽管存在大量可能的构象，但蛋白质在微秒到分钟的时间范围内折叠。对一个三链反平行β-折叠肽进行分子动力学模拟（总共12.6微秒和72次折叠事件）表明，在解链温度下，未折叠状态的集合包含的构象比折叠事件中采样的构象多得多。
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本文引用的文献
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