肿瘤坏死因子-α转化酶在中枢神经系统中的表达与功能

Expression and function of tumour necrosis factor-alpha-converting enzyme in the central nervous system.

作者信息

Moro Maria A, Hurtado Olivia, Cárdenas Antonio, Romera Cristina, Madrigal Jose L M, Fernández-Tomé Paz, Leza Juan C, Lorenzo Pedro, Lizasoain Ignacio

机构信息

Departamento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.

出版信息

Neurosignals. 2003 Mar-Apr;12(2):53-8. doi: 10.1159/000071814.

DOI:10.1159/000071814

PMID:12876399

Abstract

Tumour necrosis factor-alpha (TNF-alpha)-converting enzyme (TACE/ADAM17) is a membrane protein belonging to the ADAM (a disintegrin and a metalloprotease) family able to cleave various membrane proteins, including the transmembrane form of TNF-alpha at its physiological processing site. Being an ADAM, TACE may mediate not only proteolysis but also adhesive interactions; however, the role of the disintegrin domain of TACE has not been studied. In the central nervous system (CNS), little is known about the physiological role of TACE, but some important pathophysiological functions have been reported recently, with both neurotoxic and neuroprotective repercussions. This article discusses and reviews the main contributions to this field of investigation addressing the expression and function of TACE in the CNS.

摘要

肿瘤坏死因子-α（TNF-α）转换酶（TACE/ADAM17）是一种膜蛋白，属于ADAM（一种去整合素和金属蛋白酶）家族，能够切割多种膜蛋白，包括在其生理加工位点的跨膜形式的TNF-α。作为一种ADAM，TACE不仅可以介导蛋白水解，还可以介导黏附相互作用；然而，TACE去整合素结构域的作用尚未得到研究。在中枢神经系统（CNS）中，人们对TACE的生理作用知之甚少，但最近报道了一些重要的病理生理功能，具有神经毒性和神经保护作用。本文讨论并综述了该研究领域中关于TACE在中枢神经系统中的表达和功能的主要贡献。