Hamel E
Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Pharmacol Ther. 1992;55(1):31-51. doi: 10.1016/0163-7258(92)90028-x.
This paper summarizes published data on the interactions of tubulin with antimitotic compounds that inhibit the binding of vinca alkaloids to the protein. These are all relatively complex natural products isolated from higher plants, fungi and marine invertebrate animals. These agents are maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B and their congeners. Effects on tubulin polymerization, ligand binding interactions and structure-activity relationships are emphasized.
本文总结了已发表的关于微管蛋白与抗有丝分裂化合物相互作用的数据，这些化合物可抑制长春花生物碱与该蛋白的结合。这些都是从高等植物、真菌和海洋无脊椎动物中分离出的相对复杂的天然产物。这些药物包括美登素、根霉素、腐草霉素A、多拉司他汀10和15以及海兔毒素B及其类似物。文中重点阐述了它们对微管蛋白聚合、配体结合相互作用以及构效关系的影响。
