Araki Shin-ichi, Haneda Masakazu
Department of Medicine, Shiga University of Medical Science.
Nihon Rinsho. 2003 Jul;61(7):1124-9.
There is a unique relationship between the kidney and blood pressure. The importance of the kidney on the pathogenesis of hypertension was clearly demonstrated in renal transplantation studies both in genetic hypertensive rats and humans with hypertension. Also, hypertension accelerates loss of function of the diseased kidney and the antihypertensive treatment attenuates the progression of various renal diseases. A lot of mechanisms to explain this relationship are considered: salt retention, abnormalities of renal hemodynamics, inappropriate activation of the renin-angiotensin system etc. This review is an attempt to highlight a renal role on the development of hypertension, especially in diabetic nephropathy.
肾脏与血压之间存在独特的关系。在遗传性高血压大鼠和高血压患者的肾移植研究中，肾脏在高血压发病机制中的重要性得到了明确证实。此外，高血压会加速患病肾脏的功能丧失，而降压治疗可减缓各种肾脏疾病的进展。人们考虑了许多解释这种关系的机制：盐潴留、肾血流动力学异常、肾素 - 血管紧张素系统的不适当激活等。本综述旨在强调肾脏在高血压发生发展中的作用，尤其是在糖尿病肾病中。
