Itoh Hiroshi
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine.
Nihon Rinsho. 2003 Jul;61(7):1145-53.
Diabetes mellitus and hypertension frequently occur in the same individual, based upon 'insulin resistance', which is caused by obesity and impairment of secretion of several adipocyte-derived hormones(adipocytokines), including leptin and adiponectin. Insulin resistance and activation of tissue renin-angiotensin system mutually affect each other to promote diabetes mellitus/hypertension and their complications. Especially, renin-angiotensin system in the adipose tissue modulate adipocyte differentiation and adipose tissue mass. Vascular renin-angiotensin system causes endothelial dysfunction and promotes inflammatory process to accelerate atherosclerosis. Blockade of renin-angiotensin system is reasonable for prevention and suppression of diabetes mellitus/hypertension and their complications.
糖尿病和高血压常发生于同一个体，这是基于“胰岛素抵抗”，其由肥胖以及包括瘦素和脂联素在内的几种脂肪细胞衍生激素（脂肪细胞因子）分泌受损所致。胰岛素抵抗与组织肾素 - 血管紧张素系统的激活相互影响，从而促进糖尿病/高血压及其并发症的发生。特别是，脂肪组织中的肾素 - 血管紧张素系统调节脂肪细胞分化和脂肪组织量。血管肾素 - 血管紧张素系统导致内皮功能障碍并促进炎症过程，从而加速动脉粥样硬化。阻断肾素 - 血管紧张素系统对于预防和抑制糖尿病/高血压及其并发症是合理的。
