Aitken M M, Hall E, Scott L, Davot J L, Allen W M
Compton Paddock Laboratories, Unit 8, Frilsham Home Farm Units, Yattendon, Thatcham, Berkshire.
Vet Rec. 2003 Jul 5;153(1):13-6. doi: 10.1136/vr.153.1.13.
The concentrations of phenobarbitone, albumin, bile acids and cholesterol, and the activities of alkaline phosphatase (AP), alanine aminotransferase (ALT), gamma glutamyl transferase (GGT) and glutamate dehydrogenase (GLDH) were measured in the serum of 95 epileptic dogs whose clinical signs were controlled with phenobarbitone. The dogs were divided into groups on the basis of the concentration of phenobarbitone in their serum, the dose administered and the duration of the treatment. The concentration of phenobarbitone in serum was directly related to the activities of ALT, AP, GGT and GLDH and inversely related to the concentration of albumin. There was no significant relationship between the duration of treatment and the serum concentration of phenobarbitone, but there was a significant relationship between the duration of treatment and the activities of ALT, AP and GLDH. Thirty-five of the dogs (37 per cent) had serum activities of AP above the normal range, 19 had abnormally high activities of ALT, and 15 had high activities of GLDH, but these incidences were not related to the serum concentration of phenobarbitone. The dogs receiving higher doses for longer periods had the highest incidence of high activities of AP, ALT and GLDH. The concentration of bile acids in seven of the dogs was above the normal range but there was no relationship between the concentration and either the serum concentration, dose or duration of treatment with phenobarbitone.
对95只临床症状已被苯巴比妥控制的癫痫犬的血清进行了苯巴比妥、白蛋白、胆汁酸和胆固醇浓度以及碱性磷酸酶（AP）、丙氨酸氨基转移酶（ALT）、γ-谷氨酰转移酶（GGT）和谷氨酸脱氢酶（GLDH）活性的测定。根据血清中苯巴比妥的浓度、给药剂量和治疗持续时间将这些犬分为不同组。血清中苯巴比妥的浓度与ALT、AP、GGT和GLDH的活性直接相关，与白蛋白浓度呈负相关。治疗持续时间与苯巴比妥血清浓度之间无显著关系，但治疗持续时间与ALT、AP和GLDH的活性之间存在显著关系。35只犬（37%）的AP血清活性高于正常范围，19只犬的ALT活性异常高，15只犬的GLDH活性高，但这些发生率与苯巴比妥的血清浓度无关。接受更高剂量且治疗时间更长的犬，AP、ALT和GLDH活性高的发生率最高。7只犬的胆汁酸浓度高于正常范围，但该浓度与苯巴比妥的血清浓度、剂量或治疗持续时间均无关系。
