Marcelli M, McPhaul M J
Department of Internal Medicine, Baylor College of Medicine, Houston.
Recenti Prog Med. 1992 Nov;83(11):605-13.
Androgen resistance is responsible for the development of a spectrum of abnormalities of male sexual differentiation, and can be broadly divided in two categories: deficiency of 5-alpha-reductase and defects in the androgen receptor. Recent developments in the field on molecular biology have allowed the cloning and characterization of the genes responsible for both syndromes and have made it possible to detect the subtle molecular defects underlying these diseases. This discussion will review some of the most recent development in this field of research.
雄激素抵抗导致了一系列男性性分化异常的发生，大致可分为两类：5-α还原酶缺乏和雄激素受体缺陷。分子生物学领域的最新进展使得导致这两种综合征的基因得以克隆和表征，并能够检测出这些疾病潜在的细微分子缺陷。本讨论将回顾该研究领域的一些最新进展。
