Schenk K E, Gross U, Oehring L, Schmidt H
Recent Adv Stud Cardiac Struct Metab. 1975;10:655-60.
In a long term experiment, a systematic analysis was made of the cellular reaction of the myocardium and the lymphatic system to application of antigenic substances. Several groups of mice received single or repeated injections of human serum, serum from rabbits with antiheart antibodies, mouse spleen cells immunized to myocardium, and human or mouse cardiac homogenate with and without incomplete or complete Freund's adjuvant. After injection of human and mouse heart homogenate, hypertrophy of myocardial cells was the first alteration seen; then followed focal myocarditis and after 10 months, interstitial fibrosis. Simultaneously, in the lymphorecticular tissue, there was marked proliferation of reticulum cells, lymphocytes, and plasma cells, as well as an enlargement of secondary follicles. All the animals produced antibodies to the injected antigens. Following injection of human serum or serum from rabbits with cardiac specific antibodies or spleen cells, no morphological changes were seen in the hearts.
在一项长期实验中，对心肌和淋巴系统对抗抗原物质的细胞反应进行了系统分析。几组小鼠接受了单次或重复注射人血清、来自有抗心脏抗体兔子的血清、免疫至心肌的小鼠脾细胞，以及添加或不添加不完全或完全弗氏佐剂的人或小鼠心脏匀浆。注射人及小鼠心脏匀浆后，心肌细胞肥大是首先观察到的改变；随后是局灶性心肌炎，10个月后出现间质纤维化。同时，在淋巴网状组织中，网状细胞、淋巴细胞和浆细胞显著增殖，次级滤泡也增大。所有动物都产生了针对注射抗原的抗体。注射人血清、来自有心脏特异性抗体兔子的血清或脾细胞后，心脏未观察到形态学变化。
