Pincemail J, Defraigne J O, Franssen C, Meurisse M, Deby C
Centre Interdisciplinaire de l'Oxygène normal et pathologique, Université de Liège, Belgique.
Acta Gastroenterol Belg. 1992 Sep-Dec;55(5-6):437-45.
One of the major cause of human disease results from the compromise of blood flow and oxygen delivery to tissues. Ischemia phenomenon is defined as blood flow that is inadequate to maintain normal tissue function. Prolonged ischemia ultimately results in irreversible changes in cell metabolism and cell death. Historically, it was felt that if ischemia results in altered cell function and injury, then reoxygenation or reperfusion leading to a restoration of a normal blood flow was expected to have a beneficial effect and promote salvage of tissue depending on the extent of ischemia. Recent studies have, however, revealed that reoxygenation leads to an oxygen metabolism resulting in the generation of active and toxic oxygen intermediates (free radicals) which play an important role in the pathophysiology of reperfusion injury.
人类疾病的主要原因之一是组织的血流和氧气输送受到影响。缺血现象被定义为不足以维持正常组织功能的血流。长时间缺血最终会导致细胞代谢发生不可逆变化并导致细胞死亡。从历史上看，人们认为如果缺血导致细胞功能改变和损伤，那么恢复正常血流的再氧合或再灌注有望产生有益效果，并根据缺血程度促进组织挽救。然而，最近的研究表明，再氧合会导致氧代谢，产生活性和有毒的氧中间体（自由基），它们在再灌注损伤的病理生理学中起重要作用。
