Risperidone-induced obsessive-compulsive symptoms in two children.
作者信息
Diler Rasim Somer, Yolga Aysegul, Avci Ayse, Scahill Lawrence
机构信息
Department of Child and Adolescent Psychiatry, Faculty of Medicine, Cukurova University, Balcali, Adana, Turkey.
出版信息
J Child Adolesc Psychopharmacol. 2003;13 Suppl 1:S89-92. doi: 10.1089/104454603322126386.
OBJECTIVE
To present two cases of rapid-onset obsessive-compulsive symptoms in children treated with risperidone.
CASES
"A" was an 8-year-old boy with attention deficit and chronic tic disorder who developed obsessive-compulsive symptoms within 2 weeks of starting risperidone. When the dose of 0.5 mg tid was discontinued, the obsessive-compulsive symptoms resolved with no return over 8 months of follow-up. "B" was an 11-year-old girl with mild mental retardation and aggression who was treated with risperidone 1 mg per day. Obsessive-compulsive symptoms suddenly emerged 10 days after starting risperidone and resolved within 3 days of discontinuation. In both cases, streptococcal pharyngitis was ruled out.
CONCLUSION
Although the mechanism is not clear, these cases add to several other reports concerning the sudden emergence of obsessive-compulsive symptoms and anxiety symptoms in children treated with atypical antipsychotics. Clinicians should be alert to the possibility of these adverse effects in children treated with these drugs.
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