利培酮治疗的精神分裂症患者短期强迫症状减轻：一项单盲前瞻性研究。
Reduced short-term obsessive-compulsive symptoms in schizophrenic patients treated with risperidone: a single-blind prospective study.
作者信息
Veznedaroglu Baybars, Ercan Eyup Sabri, Kayahan Bulent, Varan Azmi, Bayraktar Erhan
机构信息
Department of Psychiatry, School of Medicine, Ege University, Bornova, Izmir, Turkey.
出版信息
Hum Psychopharmacol. 2003 Dec;18(8):635-40. doi: 10.1002/hup.536.
BACKGROUND
Risperidone is a widely used agent as first-line treatment in schizophrenia with a favorable side-effect profile. However, a number of case reports have suggested an increase in obsessive-compulsive symptoms in patients treated with risperidone.
OBJECTIVE
The aim of this study was to investigate the effect of risperidone on obsessive-compulsive symptoms in the treatment of schizophrenia.
METHOD
Forty patients with DSM-IV diagnosis of schizophrenia were included in the study. The Yale-Brown obsessive compulsive scale was administered before, at the end of first and second months of treatment. Paired-samples t-test was used to compare the three assessments.
RESULTS
There was not an increase, but a significant decrease, in YBOCS scores over time during risperidone treatment (p<0.05).
CONCLUSION
In the present study risperidone caused a significant decrease in obsessive-compulsive symptoms in the treatment of schizophrenia.
背景
利培酮是一种广泛用作精神分裂症一线治疗的药物，具有良好的副作用特征。然而，一些病例报告表明，接受利培酮治疗的患者强迫症状有所增加。
目的
本研究旨在探讨利培酮在治疗精神分裂症时对强迫症状的影响。
方法
本研究纳入了40例符合DSM-IV精神分裂症诊断标准的患者。在治疗的第一个月和第二个月末及治疗前使用耶鲁-布朗强迫量表进行评估。采用配对样本t检验对三次评估结果进行比较。
结果
在利培酮治疗期间，YBOCS评分随时间推移没有增加，反而显著下降（p<0.05）。
结论
在本研究中，利培酮在治疗精神分裂症时可使强迫症状显著减轻。
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