Hudetz A G, Kiani M F
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226.
Adv Exp Med Biol. 1992;316:31-9. doi: 10.1007/978-1-4615-3404-4_4.
The possible role of wall shear stress in microvascular network adaptation was investigated by computer simulation in planar polygonal model networks. Adaptation of vessel diameter to local wall shear stress resulted in false geometry and excessive rarefaction of the networks. Adaptation to mean wall shear stress decreased the range of shear stress, decreased the total power dissipation, and prevented network rarefaction. A measure of mean wall shear stress may serve as a control signal for the adaptation of vessel diameter to blood flow in microvascular networks.
通过平面多边形模型网络的计算机模拟研究了壁面剪应力在微血管网络适应性中的可能作用。血管直径对局部壁面剪应力的适应导致网络几何形状失真和过度稀疏。对平均壁面剪应力的适应降低了剪应力范围，降低了总功耗，并防止了网络稀疏。平均壁面剪应力的一种度量可以作为微血管网络中血管直径适应血流的控制信号。
