过度通气对新生儿大脑皮层氧合作用的影响。

Effect of hyperventilation on oxygenation of the brain cortex of neonates.

作者信息

Wilson D F, Pastuszko A, Schneiderman R, DiGiacomo J E, Pawlowski M, Delivoria-Papadopoulos M

机构信息

Department of Biochemistry and Biophysics, Medical School, University of Pennsylvania, Philadelphia 19104.

出版信息

Adv Exp Med Biol. 1992;316:341-6. doi: 10.1007/978-1-4615-3404-4_39.

DOI:10.1007/978-1-4615-3404-4_39

PMID:1288095

Abstract

A new phosphorescence imaging method (Rumsey et al, Science (1988) 1649) has been used to continuously monitor the oxygen pressure in the blood of the cerebral cortex of newborn pigs. The animals' blood pressure was continuously measured and PaCO2, PaO2 and arterial blood pH were measured periodically. The oxygen pressure in the blood was quantitatively determined for regions of about 100 um square within the image (from a total field of about 3 mm diameter). It was observed that during hyperventilation, which lowered PaCO2 and increased pH of the blood, oxygen pressure decreased in proportion to the decrease in PaCO2. For example, hyperventilation which decreased PaCO2 from its normal value of 40 Torr to 10 Torr caused a rapid (within 5 minutes) decrease in oxygen pressure in the blood of capillaries and veins to approximately 1/4 of normal.

摘要

一种新的磷光成像方法（拉姆齐等人，《科学》（1988年）第1649页）已被用于连续监测新生猪大脑皮质血液中的氧分压。持续测量动物的血压，并定期测量动脉血二氧化碳分压（PaCO2）、动脉血氧分压（PaO2）和动脉血pH值。对图像中约100平方微米的区域（来自直径约3毫米的整个视野）定量测定血液中的氧分压。据观察，在导致PaCO2降低和血液pH值升高的过度通气过程中，氧分压与PaCO2的降低成比例下降。例如，将PaCO2从其正常值40托降低到10托的过度通气会导致毛细血管和静脉血液中的氧分压在5分钟内迅速下降至正常水平的约四分之一。