Scherrer Jeffrey F, Xian Hong, Bucholz Kathleen K, Eisen Seth A, Lyons Michael J, Goldberg Jack, Tsuang Ming, True William R
School of Public Health, St. Louis University Health Sciences Center, Missouri, USA.
Psychosom Med. 2003 Jul-Aug;65(4):548-57. doi: 10.1097/01.psy.0000077507.29863.cb.
Epidemiological and clinical studies have established an association between major depression and cardiovascular disease. We utilized a twin design to test whether there are common genetic and environmental risk factors underlying depression symptoms, hypertension and heart disease.
Association studies were conducted with 6,903 male-male twins from the Vietnam Era Twin Registry who responded to both a 1990 health questionnaire and a 1992 telephone administration of a structured psychiatric interview. Data from 2,731 complete twin pairs were used to fit genetic models which determined the extent to which lifetime depression symptoms, heart disease and hypertension shared genetic and/or environmental factors.
Heart disease was significantly associated with 1-4 symptoms and 5 or more symptoms of depression (odds ratio [OR] = 2.62; 95% confidence interval [CI]: 1.54-4.46 and OR = 4.02; 95% CI: 2.16-7.46). Hypertension was significantly associated with 1 to 4 symptoms and 5 or more symptoms of depression (OR = 1.29; 95% CI: 1.11-1.50 and OR = 1.49; 95% CI: 1.21-1.83). The genetic correlations were significant between depression symptoms and hypertension (r =.19), and between depression symptoms and heart disease (r =.42). Of the total variance in depression, 8% was common to hypertension and heart disease, 7% of the variance in hypertension was common with depression symptoms and heart disease, and 64% of the variance in heart disease was common with depression symptoms and hypertension.
Men who reported cardiovascular disease were significantly more likely to have depression symptoms. The lifetime co-occurrence of these phenotypes is partly explained by common genetic risk factors.
流行病学和临床研究已证实重度抑郁症与心血管疾病之间存在关联。我们采用双生子设计来检验抑郁症状、高血压和心脏病是否存在共同的遗传和环境风险因素。
对来自越南战争时期双生子登记处的6903对男性双生子进行关联研究，这些双生子对1990年的健康问卷和1992年的结构化精神科访谈电话调查都做出了回应。来自2731对完整双生子的数据用于拟合遗传模型，以确定终生抑郁症状、心脏病和高血压在多大程度上共享遗传和/或环境因素。
心脏病与1 - 4种抑郁症状以及5种或更多抑郁症状显著相关（优势比[OR]=2.62；95%置信区间[CI]：1.54 - 4.46；OR = 4.02；95% CI：2.16 - 7.46）。高血压与1至4种抑郁症状以及5种或更多抑郁症状显著相关（OR = 1.29；95% CI：1.11 - 1.50；OR = 1.49；95% CI：1.21 - 1.83）。抑郁症状与高血压之间的遗传相关性显著（r =.19），抑郁症状与心脏病之间的遗传相关性也显著（r =.42）。在抑郁的总变异中，8%与高血压和心脏病共有，高血压变异的7%与抑郁症状和心脏病共有，心脏病变异的64%与抑郁症状和高血压共有。
报告患有心血管疾病的男性出现抑郁症状的可能性显著更高。这些表型的终生共现部分由共同的遗传风险因素解释。
