Cermak Jennifer M, Krenzer Kathleen L, Sullivan Rose M, Dana M Reza, Sullivan David A
Schepens Eye Research Institute, 20 Staniford Street, Boston, Massachusetts 02114, USA.
Cornea. 2003 Aug;22(6):516-21. doi: 10.1097/00003226-200308000-00006.
This study's purpose was to determine whether complete androgen insensitivity syndrome (CAIS) is associated with alterations in the meibomian gland and ocular surface.
Individuals with CAIS, as well as age-matched female and male controls, completed questionnaires which assessed dry eye symptoms and underwent slit lamp evaluations of the tear film, tear meniscus, lids and lid margins and conjunctiva. The quality of meibomian gland secretions was also analyzed.
Our results demonstrate that CAIS is associated with meibomian gland alterations and a significant increase in dry eye signs and symptoms. Clinical assessment revealed that CAIS women, as compared to controls, had a significant increase in telangiectasia, keratinization, lid erythema and orifice metaplasia of the meibomian glands, and a significant decrease in the tear meniscus and quality of meibomian gland secretions. Questionnaire results showed that dry eye symptoms were increased over twofold in CAIS individuals, as compared to controls, including a significant increase in the sensations of dryness, pain and light sensitivity.
Our results suggest that androgen insensitivity may promote meibomian gland dysfunction and an increase in the signs and symptoms of dry eye.
本研究旨在确定完全性雄激素不敏感综合征（CAIS）是否与睑板腺及眼表改变有关。
患有CAIS的个体以及年龄匹配的女性和男性对照者完成了评估干眼症状的问卷，并接受了裂隙灯对泪膜、泪液弯月面、眼睑及睑缘和结膜的评估。还分析了睑板腺分泌物的质量。
我们的结果表明，CAIS与睑板腺改变以及干眼体征和症状的显著增加有关。临床评估显示，与对照组相比，患有CAIS的女性睑板腺的毛细血管扩张、角化、眼睑红斑和开口化生显著增加，泪液弯月面和睑板腺分泌物质量显著下降。问卷调查结果显示，与对照组相比，CAIS个体的干眼症状增加了两倍多，包括干涩、疼痛和光敏感等感觉显著增加。
我们的结果表明，雄激素不敏感可能会促进睑板腺功能障碍并增加干眼的体征和症状。
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