Cherpes Thomas L, Meyn Leslie A, Krohn Marijane A, Lurie Joel G, Hillier Sharon L
Department of Medicine, Division of Infectious Disease, University of Pittsburgh, Pittsburgh, PA, USA.
Clin Infect Dis. 2003 Aug 1;37(3):319-25. doi: 10.1086/375819. Epub 2003 Jul 15.
A longitudinal cohort study of sexually active women 18-30 years of age was conducted to identify variables associated with the acquisition of herpes simplex virus type 2 (HSV-2) infections. Six hundred seventy HSV-2-seronegative women were followed up at 4-month intervals for 1 year; acquisition of HSV-2 antibodies was detected in 32 of these women. Black race, < or =12 years of education, having a new sex partner, and bacterial vaginosis (BV) were associated with HSV-2 seroconversion on univariate analysis. Antecedent HSV-1 infection was not protective against HSV-2 acquisition. After controlling for other identified risk factors in multivariable models, the diagnosis of BV remained associated with an increased risk of acquiring HSV-2 infection (hazard ratio, 2.1; 95% confidence interval, 1.0-4.5; P=.05). In this study, the population attributable risk of BV for HSV-2 seroconversion was 21%. Additional studies are needed to determine whether screening and treatment of BV could reduce susceptibility to the acquisition of HSV-2 in women.
对18至30岁性活跃女性进行了一项纵向队列研究，以确定与获得2型单纯疱疹病毒（HSV-2）感染相关的变量。670名HSV-2血清阴性女性每隔4个月随访1年；其中32名女性检测到获得了HSV-2抗体。单因素分析显示，黑人种族、受教育年限≤12年、有新的性伴侣以及细菌性阴道病（BV）与HSV-2血清转化有关。既往HSV-1感染对获得HSV-2没有保护作用。在多变量模型中控制其他已确定的危险因素后，BV诊断仍与获得HSV-2感染的风险增加相关（风险比，2.1；95%置信区间，1.0 - 4.5；P = 0.05）。在本研究中，BV导致HSV-2血清转化的人群归因风险为21%。需要进一步研究以确定对BV进行筛查和治疗是否可以降低女性获得HSV-2的易感性。
