[实验室小鼠脑重量与乙醇给药后行为变化之间的相关性]

[The correlation between brain weight and behavior changes in response to ethanol administration in laboratory mice].

作者信息

Markina N V, Salimov R M, Perepelkina O V, Maĭskiĭ A I, Poletaeva I I

机构信息

Department of Higher Neural Activity, Lomonosov Moscow State University, Moscow, 119899 Russia.

出版信息

Genetika. 2003 Jun;39(6):826-30.

PMID:12884523

Abstract

The effects of ethanol injections on the F2 offspring of the cross between large-brain (LB) and small-brain (SB) mouse strains selected for high and low relative brain weights, respectively, have been studied. The parental strains have significantly differed in brain weight for many generations. The effects of ethanol (2.4 g/kg) have been compared in four subpopulations of mice that differ pairwise in brain weight. One pair of subpopulations has been isolated from the hybrid group and the other, from generation 22 of selection of the parental strains. The results of ANOVA have demonstrated that brain weight is related to the response to ethanol injections. The parameters of stereotyped behavior, which increased in after ethanol injections and reflected the decrease in exploratory activity) were different in mice with high and low relative brain weights. The pattern of behavioral changes after ethanol injections is the second (after increased learning ability) behavioral trait found to be correlated with brain weight.

摘要

已对乙醇注射对分别选择用于高和低相对脑重的大脑型（LB）和小脑型（SB）小鼠品系杂交的F2代后代的影响进行了研究。亲本品系在许多代中脑重都有显著差异。已在脑重两两不同的四个小鼠亚群中比较了乙醇（2.4 g/kg）的影响。其中一对亚群是从杂交组中分离出来的，另一对则是从亲本品系选择的第22代中分离出来的。方差分析结果表明，脑重与对乙醇注射的反应有关。刻板行为参数在乙醇注射后增加，反映了探索活动的减少，在相对脑重高和低的小鼠中有所不同。乙醇注射后的行为变化模式是发现与脑重相关的第二个（继学习能力提高之后）行为特征。