Perepelkina Olga V, Poletaeva Inga I
Biology Department, Lomonossov Moscow State University, Vorobievy Gory, 1, Building 12, Moscow 119234, Russia.
Neurol Int. 2023 May 15;15(2):649-660. doi: 10.3390/neurolint15020041.
In this paper, the data are presented concerning different reactions to seven daily injections of atomoxetine in two mouse strains differing in relative brain weight. Atomoxetine affected the performance in a puzzle-box cognitive test in a complicated way-the large brain mice were less successful at task solutions (presumably because they were not afraid of the brightly lit test box), while the small brain strain of atomoxetine treated mice solved the task more successfully. The behavior of all atomoxetine treated animals was more active in an aversive situation (an unescapable slippery funnel, (analogous to the Porsolt test) and the time of immobility decreased significantly in all atomoxetine treated mice. The general patterns of behavioral reactions to atomoxetine in the cognitive test and other interstrain differences demonstrated in these experiments made it possible to suggest that differences in ascending noradrenergic projections between the two strains used exist. Further analysis of the noradrenergic system in these strains is needed (and further analysis of the effects of drugs which affect noradrenergic receptors).
本文呈现了关于两种相对脑重不同的小鼠品系对每日注射七次托莫西汀的不同反应的数据。托莫西汀以一种复杂的方式影响了迷宫箱认知测试中的表现——大脑型小鼠在任务解决方面不太成功（可能是因为它们不怕明亮的测试箱），而接受托莫西汀治疗的小脑型小鼠品系更成功地解决了任务。在厌恶情境（一个无法逃脱的滑漏斗，类似于波索尔特测试）中，所有接受托莫西汀治疗的动物行为更活跃，并且所有接受托莫西汀治疗的小鼠的不动时间显著减少。这些实验中所展示的在认知测试中对托莫西汀的行为反应总体模式以及其他品系间差异表明，所使用的两种品系之间存在去甲肾上腺素能上行投射的差异。需要对这些品系中的去甲肾上腺素能系统进行进一步分析（以及对影响去甲肾上腺素能受体的药物的作用进行进一步分析）。
