Bednarz Bronisław
Szpital Grochowski, Klinika Kardiologii CMKP 04-073 Warszawa, ul. Grenadierów 51/59.
Przegl Lek. 2003;60(1):27-9.
This review describes the role of statins in the primary and secondary prevention of coronary artery disease and the clinical benefit of therapy with statins in different forms of coronary artery disease (stable, unstable and myocardial infarction). Presented clinical trials have provided data that statins not only reduce plasma total cholesterol and LDL-cholesterol levels but also reduce major coronary event rate and all-cause mortality. Treatment with statins is usually well tolerated. The mean total cost of care to reach LDL-cholesterol target is significantly lower with atorvastatin than with the other statins.
本综述描述了他汀类药物在冠状动脉疾病一级和二级预防中的作用，以及他汀类药物治疗不同形式冠状动脉疾病（稳定型、不稳定型和心肌梗死）的临床获益。现有临床试验提供的数据表明，他汀类药物不仅能降低血浆总胆固醇和低密度脂蛋白胆固醇水平，还能降低主要冠状动脉事件发生率和全因死亡率。他汀类药物治疗通常耐受性良好。阿托伐他汀达到低密度脂蛋白胆固醇目标的平均总护理成本显著低于其他他汀类药物。
