粘着斑激酶（FAK）调节对癌症发病机制至关重要的生物学过程。

FAK regulates biological processes important for the pathogenesis of cancer.

作者信息

Gabarra-Niecko Veronica, Schaller Michael D, Dunty Jill M

机构信息

Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

出版信息

Cancer Metastasis Rev. 2003 Dec;22(4):359-74. doi: 10.1023/a:1023725029589.

DOI:10.1023/a:1023725029589

PMID:12884911

Abstract

Since its initial discovery as a substrate and binding partner for the Src oncogene, a role for the focal adhesion kinase (FAK) in cancer has been speculated. In this review the clinical evidence correlating FAK overexpression with cancer and the experimental evidence demonstrating that FAK can control some phenotypes associated with cancer will be discussed. In addition, the emerging theme of interactions between the FAK and growth factor signaling pathways will be described. The evidence presented in this review provides a compelling case for a role for FAK in the pathology of human cancer.

摘要

自作为Src癌基因的底物和结合伴侣首次被发现以来，粘着斑激酶（FAK）在癌症中的作用就一直被推测。在这篇综述中，将讨论FAK过表达与癌症相关的临床证据，以及证明FAK可控制某些与癌症相关表型的实验证据。此外，还将描述FAK与生长因子信号通路之间相互作用这一新兴主题。这篇综述中呈现的证据为FAK在人类癌症病理学中的作用提供了令人信服的依据。