Li Chong, Wang Yu, Zhang Wenjing, Yang Xiaoman, Wang Yufang, Hou Guanqun, Wang Dongli, Han Bingbing, Zhang Yimin
College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Department of Spleen and Stomach, Hospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan, China.
Front Oncol. 2024 Dec 11;14:1506588. doi: 10.3389/fonc.2024.1506588. eCollection 2024.
Glabridin, a flavonoid derived from the plant , has garnered significant attention due to its diverse pharmacological effects, including antioxidant, antibacterial, anti-inflammatory, hypolipidemic, and hypoglycemic activities. Studies have shown that glabridin exhibits substantial antitumor activity by modulating the proliferation, apoptosis, metastasis, and invasion of cancer cells through the targeting of various signaling pathways, thus indicating its potential as a therapeutic agent for malignant tumors. To enhance its solubility, stability, and bioavailability, several drug delivery systems have been developed, including liposomes, cyclodextrin inclusion complexes, nanoparticles, and polymeric micelles. These de.livery systems have shown promise in preclinical studies but face challenges in clinical translation, such as issues with biocompatibility, delivery efficiency, and long-term stability. A comprehensive analysis of the antitumor mechanism of glabridin and its novel drug delivery system is still lacking. Therefore, the authors performed a comprehensive review of recent literature on the antitumor effects of glabridin and its novel drug delivery systems, covering the antitumor mechanism, action targets, and novel drug delivery systems, offering new theoretical insights and development directions for its further advancement and clinical application.
光甘草定是一种从植物中提取的黄酮类化合物，因其具有抗氧化、抗菌、抗炎、降血脂和降血糖等多种药理作用而备受关注。研究表明，光甘草定通过靶向多种信号通路调节癌细胞的增殖、凋亡、转移和侵袭，从而表现出显著的抗肿瘤活性，这表明它具有作为恶性肿瘤治疗药物的潜力。为了提高其溶解度、稳定性和生物利用度，人们开发了几种药物递送系统，包括脂质体、环糊精包合物、纳米颗粒和聚合物胶束。这些递送系统在临床前研究中显示出了前景，但在临床转化中面临挑战，如生物相容性、递送效率和长期稳定性等问题。目前仍缺乏对光甘草定及其新型药物递送系统抗肿瘤机制的全面分析。因此，作者对最近关于光甘草定及其新型药物递送系统抗肿瘤作用的文献进行了全面综述，涵盖了抗肿瘤机制、作用靶点和新型药物递送系统，为其进一步发展和临床应用提供了新的理论见解和发展方向。
