Sampson D, Grotelueschen C, Kauffman H M
Transplantation. 1975 Nov;20(5):362-7. doi: 10.1097/00007890-197511000-00002.
Studies of human spleen cell suspensions show that they contain a population of cells which can inhibit the mixed lymphocyte reaction. The cells appear to be able to suppress the patient's own response to an antigenic challenge in slightly greater degree than their ability to suppress a nonspecific mixed lymphocyte culture. The suppressive effect is dependent on cell dose and is linearly related to the log of cell concentration. At low dose these cells have no suppressive effect and, in fact, behave as stimulators. Exposure of these cells to an environment containing immunosuppressive drug abrogates their suppressor activity. Manipulation of these cells may prove to be of value in the control of graft rejection.
对人脾细胞悬液的研究表明，它们含有一群能够抑制混合淋巴细胞反应的细胞。这些细胞似乎能够在比抑制非特异性混合淋巴细胞培养稍大的程度上抑制患者自身对抗原刺激的反应。抑制作用取决于细胞剂量，并且与细胞浓度的对数呈线性关系。在低剂量时，这些细胞没有抑制作用，实际上表现为刺激物。将这些细胞暴露于含有免疫抑制药物的环境中会消除它们的抑制活性。对这些细胞的操作可能在控制移植排斥反应中被证明具有价值。
