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酒精性胰腺炎的发病存在季节性变化,而胆源性胰腺炎则不然。

Alcoholic, but not biliary, pancreatitis varies seasonally in occurrence.

作者信息

Räty S, Sand J, Alho H, Nordback I

机构信息

Dept. of Surgery, Tampere University Hospital, Tampere, Finland.

出版信息

Scand J Gastroenterol. 2003 Jul;38(7):794-7. doi: 10.1080/00365520310003499.

Abstract

BACKGROUND

Alcohol is the most common cause of acute pancreatitis in Finland (70%). The amount of alcohol consumed has been shown to be associated with the prevalence of pancreatitis in the country, and also to be an important determinant of the severity of the first episode of acute alcoholic pancreatitis. We have a clinical suspicion that the use of alcohol and the incidence of pancreatitis are increased during holiday periods in summer, although no seasonal variations have been reported in a German population.

METHODS

Between 1972 and 1992 a total of 1556 episodes with acute alcoholic pancreatitis were treated at Tampere University Hospital; 552 were first episodes and 1004 were recurrent. For comparison, we investigated 297 episodes of acute biliary pancreatitis treated in that same time period. We investigated the monthly prevalence of acute alcoholic (first and recurrent) pancreatitis and compared this with the monthly absolute alcohol consumption.

RESULTS

Taking all alcoholic pancreatitis episodes into account, significant differences can be seen between prevalence and month of onset of the disease (P < 0.0001), whereas among biliary pancreatitis episodes there were no differences (P = 0.3). Prevalence of acute alcoholic pancreatitis was significantly higher than the expected prevalence in July and August, and the amount of alcohol consumption (100% alcohol, litres) was highest during these same months. Also during March, October and December the prevalence was higher than expected.

CONCLUSION

Months with holiday seasons, Christmas, Easter, summer and autumn, are associated with the highest alcohol consumption and the highest prevalence of acute alcoholic pancreatitis.

摘要

背景

在芬兰,酒精是急性胰腺炎最常见的病因(70%)。该国饮酒量已被证明与胰腺炎患病率相关,也是急性酒精性胰腺炎首次发作严重程度的重要决定因素。我们临床怀疑夏季节假日期间酒精使用和胰腺炎发病率会增加,尽管德国人群中尚未有季节性变化的报道。

方法

1972年至1992年间,坦佩雷大学医院共治疗了1556例急性酒精性胰腺炎发作病例;其中552例为首次发作,1004例为复发。作为对照,我们调查了同一时期治疗的297例急性胆源性胰腺炎发作病例。我们调查了急性酒精性(首次发作和复发)胰腺炎的月度患病率,并将其与月度纯酒精消费量进行比较。

结果

将所有酒精性胰腺炎发作病例考虑在内,疾病患病率与发病月份之间存在显著差异(P < 0.0001),而胆源性胰腺炎发作病例之间则无差异(P = 0.3)。急性酒精性胰腺炎患病率在7月和8月显著高于预期患病率,且同一时期酒精消费量(纯酒精,升)最高。此外,在3月、10月和12月患病率也高于预期。

结论

节假日月份,如圣诞节、复活节、夏季和秋季,与最高酒精消费量和急性酒精性胰腺炎的最高患病率相关。

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