Virkkunen M, Ebeling H, Moilanen I, Tani P, Pennanen S, Liesivuori J, Tiihonen J
Department of Psychiatry, University of Helsinki, Helsinki, Finland.
Acta Psychiatr Scand. 2003 Sep;108(3):244-6; discussion 246-7. doi: 10.1034/j.1600-0447.2003.00164.x.
Several studies have shown abnormal findings in human serotonin metabolism, such as increased total plasma l-tryptophan and free l-tryptophan levels among habitually violent antisocial offenders. It is not clear if these increased l-tryptophan levels are associated with adult antisocial personality disorder (ASP) or history of substance abuse, or if these levels are already present in adolescent subjects with conduct disorder (CD).
Total plasma and free l-tryptophan and competing amino acids (CAAs) were measured in a 15-year-old adolescent offender, who was convicted for two homicides, and in 10 healthy male controls of similar age and body mass index (BMI).
In the juvenile offender, plasma total l-tryptophan/CAA was 84% and free l-tryptophan/CAA 143% higher than average mean among controls.
From this very aggressive boy with CD, findings of free l- and total l-tryptophan/CAA values were similar to those of habitually violent adult ASP offenders. As severe CDs in adolescence tend to develop into adults with ASP, increased l-tryptophan/CAA and free l-tryptophan/CAA values may serve as early indicators for the development of habitually violent adult offenders.
多项研究表明人类血清素代谢存在异常发现，例如在习惯性暴力反社会罪犯中血浆总 l -色氨酸和游离 l -色氨酸水平升高。目前尚不清楚这些升高的 l -色氨酸水平是否与成人反社会人格障碍（ASP）或药物滥用史有关，或者这些水平在患有品行障碍（CD）的青少年受试者中是否已经存在。
对一名因两起杀人罪被定罪的 15 岁青少年罪犯以及 10 名年龄和体重指数（BMI）相似的健康男性对照者测量了血浆总 l -色氨酸、游离 l -色氨酸和竞争性氨基酸（CAA）。
在这名少年罪犯中，血浆总 l -色氨酸/CAA 比对照组平均水平高 84%，游离 l -色氨酸/CAA 比对照组平均水平高 143%。
从这名患有 CD 的极具攻击性的男孩身上发现，游离 l -色氨酸和总 l -色氨酸/CAA 值与习惯性暴力的成年 ASP 罪犯相似。由于青少年时期严重的 CD 往往会发展为患有 ASP 的成年人，升高的 l -色氨酸/CAA 和游离 l -色氨酸/CAA 值可能是习惯性暴力成年罪犯发展的早期指标。
