Keelan M, Walker K, Cheeseman C I, Thomson A B
Department of Medicine, University of Alberta, Edmonton, Canada.
Digestion. 1992;53(1-2):101-7. doi: 10.1159/000200977.
Enprostil, a synthetic E2 prostaglandin, was administered in a dose of 5 micrograms/kg body weight by gastric tube to rats for 14 days following abdominal irradiation with a single dose of 600 cGy from a 137Cs source. Enprostil prevented the body weight loss and the reduced food intake observed in irradiated animals given placebo, and also prevented the irradiation-associated decline in the mucosal weight and surface area of the ileum. Enprostil given to nonirradiated animals reduced the maximal transport rate (Vmax) and the apparent Michaelis constant (Km*) for the ileal uptake of D-glucose, but did not prevent the irradiation-associated decline in the ileal uptake of glucose. Thus, there is a dissociation of the effects of Enprostil on the morphological and the absorptive properties of the intestine. It is concluded that a 2-week course of a daily oral dose of E2 prostaglandin begun shortly after a single exposure to nonlethal abdominal irradiation prevents the radiation-associated reduction in the intestinal mucosal surface area and the animal's body weight, but does not prevent the malabsorption of glucose.
恩前列素是一种合成的E2前列腺素，在大鼠接受来自137Cs源的600 cGy单次剂量腹部照射后的14天内，通过胃管以5微克/千克体重的剂量给药。恩前列素可防止接受安慰剂的受照射动物出现体重减轻和食物摄入量减少的情况，还可防止与照射相关的回肠黏膜重量和表面积下降。给未受照射的动物服用恩前列素会降低回肠对D-葡萄糖摄取的最大转运速率（Vmax）和表观米氏常数（Km*），但不能防止与照射相关的回肠葡萄糖摄取量下降。因此，恩前列素对肠道形态和吸收特性的影响存在分离现象。得出的结论是，在单次非致死性腹部照射后不久开始，每日口服一剂E2前列腺素，持续2周的疗程可防止与辐射相关的肠黏膜表面积减少和动物体重下降，但不能防止葡萄糖吸收不良。
