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[二联律——地高辛与圣约翰草相互作用的结果]

[Bigeminy--the result of interaction between digoxin and St. John's wort].

作者信息

Andelić Sladana

机构信息

Gradski zavod za hitnu medicinsku pomoć, Beograd.

出版信息

Vojnosanit Pregl. 2003 May-Jun;60(3):361-4. doi: 10.2298/vsp0303361a.

DOI:10.2298/vsp0303361a
PMID:12891733
Abstract

A case of an by digoxin under unusual circumstances is reported. An 80-year-old man, previously on long-term digoxin treatment, started consuming St John's wort herbal tea (2,000 ml/daily) because of frequent episodes of depression. After the cessation of consuming herbal tea containing Hypericum perforatum, digoxin poisoning developed in our patient. Electrocardiography revealed nodal bradicardia 36/min and bigeminy. Manifested symptoms were the consequence of interaction between digoxin and Hypericum perforatum which were consumed simultaneously, and the cessation of consuming St John's wort herbal tea afterwards. Therapy was the same as in the standard digitalis poisoning. Consumers of St John's wort combined with medical products are advised not to discontinue tea consumption on their own, without consulting their physician.

摘要

报告了一例在不寻常情况下服用地高辛的病例。一名80岁男性,此前长期接受地高辛治疗,因频繁出现抑郁发作而开始饮用圣约翰草茶(每日2000毫升)。在停止饮用含有贯叶连翘的草药茶后,我们的患者发生了地高辛中毒。心电图显示结性心动过缓,心率36次/分钟,并有二联律。出现的症状是地高辛与同时服用的贯叶连翘相互作用的结果,之后停止饮用圣约翰草茶也导致了症状出现。治疗方法与标准洋地黄中毒相同。建议同时服用圣约翰草和药品的消费者,在未咨询医生的情况下,不要自行停止饮用该茶。

相似文献

1
[Bigeminy--the result of interaction between digoxin and St. John's wort].[二联律——地高辛与圣约翰草相互作用的结果]
Vojnosanit Pregl. 2003 May-Jun;60(3):361-4. doi: 10.2298/vsp0303361a.
2
The emerging recognition of herb-drug interactions with a focus on St. John's wort (Hypericum perforatum).对草药-药物相互作用的新认识,重点关注圣约翰草(贯叶连翘)。
Psychopharmacol Bull. 2001 Winter;35(1):53-64.
3
St John's wort and depression: slight efficacy at best, many drug interactions.圣约翰草与抑郁症:充其量只有轻微疗效,且存在多种药物相互作用。
Prescrire Int. 2004 Oct;13(73):187-92.
4
Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum).地高辛与圣约翰草(贯叶连翘)草药提取物的药代动力学相互作用。
Clin Pharmacol Ther. 1999 Oct;66(4):338-45. doi: 10.1053/cp.1999.v66.a101944.
5
Drug interactions with St John's wort : mechanisms and clinical implications.与圣约翰草的药物相互作用:作用机制及临床意义
Drug Saf. 2004;27(11):773-97. doi: 10.2165/00002018-200427110-00003.
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Effect of St John's wort dose and preparations on the pharmacokinetics of digoxin.圣约翰草的剂量和制剂对地高辛药代动力学的影响。
Clin Pharmacol Ther. 2004 Jun;75(6):546-57. doi: 10.1016/j.clpt.2004.01.014.
7
Herbal supplements and therapeutic drug monitoring: focus on digoxin immunoassays and interactions with St. John's wort.草药补充剂与治疗药物监测:聚焦地高辛免疫测定法及与圣约翰草的相互作用
Ther Drug Monit. 2008 Apr;30(2):212-7. doi: 10.1097/FTD.0b013e31816b918f.
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St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4.圣约翰草诱导肠道P-糖蛋白/多药耐药蛋白1以及肠道和肝脏中的细胞色素P450 3A4。
Clin Pharmacol Ther. 2000 Dec;68(6):598-604. doi: 10.1067/mcp.2000.112240.
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The safety of St. John's wort (Hypericum perforatum) during breastfeeding.哺乳期服用圣约翰草(贯叶连翘)的安全性。
J Clin Psychiatry. 2003 Aug;64(8):966-8. doi: 10.4088/jcp.v64n0818.
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St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties.圣约翰草(贯叶连翘):其化学、药理及临床特性综述
J Pharm Pharmacol. 2001 May;53(5):583-600. doi: 10.1211/0022357011775910.

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