Dzeban D A, Mukhtasimova N F, Pavlik L L, Moshkov D A
Educational Center of Biophysics and Physiology, Pushchino State University, Laboratory of Neuronal Ultrastructure, RAS Institute of Theoretical and Experimental Biophysics, Pushchino.
Morfologiia. 2003;123(2):33-8.
Using electron microscopic morphometry, the effect of long-term potentiation on the structure of transverse fibrillar bridges localized in a cleft of desmosome-like contacts in mixed synapses of goldfish Mauthner neurons, was studied. The number of bridges was shown to increase with the augmentation of the potentiation level of electrotonic conductivity. In contrast to control (incubation), the structure of bridges was also changed after potentiation. The paired bridges appeared that could have an arrangement within the cleft different from that one in control. On the basis of the present results in conjunction with earlier findings, the possible actin nature of these bridges was suggested. The bridge seems to represent a channel containing actin, arranged in a pattern similar to that one in nanotubules or plasmodesmas, what can, possibly, explain the stability of bridge structure observed after application of [symbol: see text] D and other extrinsic damaging factors.
利用电子显微镜形态测量法，研究了长时程增强对金鱼莫氏神经元混合突触中位于类桥粒连接裂隙处的横向纤维桥结构的影响。结果表明，随着电紧张性传导增强水平的提高，桥的数量增加。与对照（孵育）相比，增强后桥的结构也发生了变化。出现了成对的桥，其在裂隙内的排列可能与对照不同。结合目前的结果和早期的发现，推测这些桥可能具有肌动蛋白性质。桥似乎代表一个含有肌动蛋白的通道，其排列模式类似于纳米管或胞间连丝中的模式，这可能解释了在应用[符号：见正文] D和其他外在损伤因素后观察到的桥结构的稳定性。
