[人支气管分泌物的流变学特性：富含脯氨酸多肽的证实及其作用（作者译）]

[Rheological properties of human bronchial secretions: demonstration of proline-rich polypeptides and their role (author's transl)].

作者信息

Bailleul V, Richet C, Hayem A, Degand P

出版信息

Clin Chim Acta. 1977 Jan 17;74(2):115-23. doi: 10.1016/0009-8981(77)90212-1.

DOI:10.1016/0009-8981(77)90212-1

PMID:12892

Abstract

Human bronchial secretions were examined for chemical components and rheological properties. Proline-rich polypeptides (PRP) obtained by ultrasonic treatment and by contact with a cationic resin (AG 50WX2) were purified by gel-filtration chromatography and high-voltage electrophoresis. The chemical composition of these components allowed a classification according to their proline, glycine, glutamic acid and lysine contents. Rheological experiments suggest a biological role for the PRP in the fibrillar structure of sputum.

摘要

对人类支气管分泌物进行了化学成分和流变学特性检测。通过超声处理以及与阳离子树脂（AG 50WX2）接触获得的富含脯氨酸的多肽（PRP），经凝胶过滤色谱法和高压电泳法进行纯化。这些成分的化学组成可根据其脯氨酸、甘氨酸、谷氨酸和赖氨酸含量进行分类。流变学实验表明PRP在痰液的纤维结构中具有生物学作用。

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