Söğüt Aysegül, Yilmaz Aynur, Kilinç Münire, Söğüt Arif G, Demiralay Ebru, Uzar Hatice
Baskent University Faculty of Medicine, Neurology Department.
Acta Neurol Belg. 2003 Jun;103(2):95-8.
Toxic epidermal necrolysis and Stevens-Johnson syndrome are rare, life treating cutaneous reactions. Most cases of toxic epidermal necrolysis are drug induced. The drugs with the highest estimated incidence include co-trimoxazloe (trimethoprim-sulfamethoxazole), sulfadoxine-pyrethamine, and carbamazepine. Among other drugs, the reported reaction rates are relatively low for lamotrigine and sulbactam-ampicillin. We describe a patient who developed toxic epidermal necrolysis after either administration of lamotrigine or of ampicillin.
中毒性表皮坏死松解症和史蒂文斯-约翰逊综合征是罕见的、危及生命的皮肤反应。大多数中毒性表皮坏死松解症病例是药物引起的。估计发病率最高的药物包括复方新诺明（甲氧苄啶-磺胺甲恶唑）、周效磺胺-乙胺嘧啶和卡马西平。在其他药物中，拉莫三嗪和舒巴坦-氨苄西林的报告反应率相对较低。我们描述了一名患者，在服用拉莫三嗪或氨苄西林后发生了中毒性表皮坏死松解症。
