1型神经纤维瘤病患者儿童期放疗后获得性小脑海绵状血管瘤

Acquired cerebellar cavernous angioma following childhood radiotherapy in a patient with neurofibromatosis type 1.

作者信息

Van Calenbergh Frank, Demaerel Philippe, Sciot Raf, van Loon Johan

机构信息

Department of Neurosurgery, University Hospital Gasthuisberg, Catholic University Leuven, Belgium.

出版信息

Acta Neurol Belg. 2003 Jun;103(2):103-6.

PMID:12892005

Abstract

We report the unusual case of a patient with neurofibromatosis type I, who was irradiated 16 years previously for a mesencephalic glioma causing hydrocephalus, and who developed a cerebellar haemorrhage caused by a histologically confirmed cavernous angioma, that was invisible on several earlier MRI scans. The different hypotheses concerning the de novo formation of cavernous angiomas (venous obstructive disease and genetic abnormalities) are succinctly reviewed.

摘要

我们报告了一例罕见的I型神经纤维瘤病患者，该患者16年前因中脑胶质瘤导致脑积水接受了放射治疗，后来发生了由组织学确诊的海绵状血管瘤引起的小脑出血，而该血管瘤在之前的几次MRI扫描中均未显示。本文简要回顾了关于海绵状血管瘤新生形成的不同假说（静脉阻塞性疾病和基因异常）。